Nuclear option prevents hyperinfection in the Strongyloides worm war
نویسندگان
چکیده
منابع مشابه
Nuclear option prevents hyperinfection in the Strongyloides worm war.
Humans are fighting a grinding war against parasitic nematodes. More than 100 species of nematode parasites are known to infect humans. Additionally, 1.5 billion people are infected by soil-transmitted helminths worldwide that cause an annual disease burden of 5 million years lost due to disability (YLD) (1). This disease burden is greater than the annual disease burdens of malaria (4 million Y...
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Strongyloides stercoralis is an intestinal nematode with a complex life cycle capable of a free living cycle, a parasitic cycle and autoinfection. It is usually asymptomatic in a healthy host but causes life threatening hyperinfection involving multiple organs in immunocompromised patients. However, reports of gastric involvement are very rare. This is a report of gastric strongyloidiasis with ...
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We report strongyloides hyperinfection in two patients with generalized hypogammaglobulinemia from multiple myeloma and nephrotic syndrome, despite a significant strongyloides-specific immunoglobulin G (IgG) response. In contrast to reports on animals, where human IgG was shown to be a protective antibody, our observation suggests that in humans, immunity to the infective-stage larvae is not pr...
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A case is reported of hyperinfection syndrome with Strongyloides stercoralis, with symptoms, signs and radiological appearances which led to a diagnosis of duodenal ulcer.
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The mortality in Strongyloides hyperinfection syndrome (SHS) is alarmingly high. This is particularly common in bone marrow, renal, and other solid organ transplant (SOT) patients, where figures may reach up to 50-85%. Immunosuppressives, principally corticosteroids, are the primary triggering factor. In general, the clinical features of Strongyloides stercoralis hyperinfection are nonspecific;...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2017
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1719538115